      |
|
||||||||
|
Dr. Johan van der Vlag
Research interest is focused on two main topics: glomerular diseases and transplantation immunology. Research on glomerular diseases is directed towards unravelling the underlying molecular mechanisms of proteinuria and glomerular inflammation. Research projects currently running are aimed at delineating the role of heparan sulphate proteoglycans at the structure-functional level in several glomerular diseases and identification of triggers that lead to the development of pathogenic anti-chromatin auto-antibodies in lupus. The research on transplantation immunology is directed at prolonging graft survival and is focused on the generation and application of tolerogenic dendritic cells. |
||||||||
|
Recent key publications van den Hoven MJ, Wijnhoven TJ, Li JP, Zcharia E, Dijkman HB, Wismans RG, Rops AL, Lensen JF, van den Heuvel LP, van Kuppevelt TH, Vlodavsky I, Berden JHM, Van der Vlag J: Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria. Kidney International 73:278-287, 2008 Rops AL, van den Hoven MJ, Baselmans MM, Lensen JF, Wijnhoven TJ, van den Heuvel LP, van Kuppevelt TH, Berden JH, Van der Vlag J: Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking. Kidney International 73:52-62, 2008 Rops AL, Gotte M, Baselmans MH, van den Hoven MJ, Steenbergen EJ, Lensen JF, Wijnhoven TJ, Cevikbas F, van den Heuvel LP, van Kuppevelt TH, Berden JH, Van der Vlag J: Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritis. Kidney International 72:1204-1215, 2007 Dieker JW, Fransen JH, van Bavel CC, Briand JP, Jacobs CW, Muller S, Berden JH, Van der Vlag J: Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus. Arthritis and Rheumatism 56:1921-1933, 2007 van der Heijden GW, Derijck AAHA, Posfai E, Giele M, Pelczar P, Ramos L, Wansink DG, Van der Vlag J, Peters AHFM, de Boer P: Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation. Nature Genetics 39:251-258, 2007 Dieker JW, van Bavel CC, Riemekasten G, Berden JH, Van der Vlag J: The binding of lupus-derived autoantibodies to the C-terminal peptide (83-119) of the major SmD1 autoantigen can be mediated by double-stranded DNA and nucleosomes. Annals of the Rheumatic Diseases 65:1525-1528, 2006 |
||||||||
