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P.O. Box 9101
6500 HB, Nijmegen
Geert Grooteplein zuid 8
6525 GA, Nijmegen
The Netherlands
T +31 24 3610372
F +31 24 3610373

Joop Jansen is head of molecular hematology at the Central Hematology Laboratory. He is coordinator of the molecular studies for the Leukemia Group of the European Organization for Research and Treatment of Cancer (EORTC).
Dr. Joop H. Jansen

In human leukemia, various genetic mutations are now known that are critically involved in the oncogenic transformation of the cells. Novel treatments are being designed and clinically tested that aim to correct the biological effects of the mutated proteins. Our research focuses on the molecular mechanisms that are implicated in the development of human leukemia and myelodysplastic syndromes. The biological effects of several genes that are known to be consistently mutated are studied, with a focus on various transcription factors and their downstream targets. In addition, we aim to identify novel, as yet unknown mutations that are involved in leukemogenesis.

 
Recent key publications


Feng Y, Van der Reijden BA, Lee BH, Massop M, De Witte TM, Williams IR, Gilliland DG, Jansen JH and Walsh CA, Nde1 mutations disrupt mitotic spindle function, induce chromosomal instability, and cause myeloproliferative disease, (2004) submitted
Van der Reijden BA, Massop M, Tönnissen E, Van de Locht L, Muus P, De Witte T and Jansen JH: Rapid identification of CBFB-MYH11 positive acute myeloid leukemia (AML) cases by one single MYH11 real-time RT-PCR Blood, 101: 5085-5086, 2003

Linggi B, Muller-Tidow C, Van De LL, Hu M, Nip J, Serve H, Berdel WE, Van der Reijden B, Quelle DE, Rowley JD, Cleveland J, Jansen JH, Pandolfi PP, Hiebert SW: The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia. Nature Med. 8: 743-750, 2002

Grimwade D, Biondi A , Mozziconacci M J, Hagemeijer A, Berger R , Neat M , Howe K, Dastugue N , Jansen JH, Radford-Weiss I, Lo Coco F, et al. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): Blood. (2000) 96(4):1297-308.