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Dr. Pieter Wesseling
Research interest focuses on the molecular and cellular dissection of tumour-microenvironment
interactions in brain tumours as well as on unravelling the molecular-genetic
factors that dr ive oncogenesis, particularly in glial brain tumours. The methods
used for these research topics include both morphological tissue analysis (e.g.
histology, immunohistochemistry, in situ hybridization, computerised
image analysis, tissue micro array) and molecular methods (e.g. conventional
CGH, high throughput genomic and expression array analysis, proteomics). The
studies are performed on patient material, and in animal models and in vitro models.
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Recent key publications
Bernsen H, Laak J van der, Kuesters B, Ven A van der, Wesseling P. Gliomatosis cerebri; quantitative proof of vessel recruitment by coöption in stead of angiogenesis. J Neurosurg (2005) 103:702-706.
Horssen J van , Jong D de, Waal RMW de, Maass C, Otte-Höller I, Kremer B, Verbeek MM, Wesseling P. Cerebral amyloid angiopathy with severe secondary vascular pathology: an immunohistochemical study. Dem Geriat Cogn Disorders (2005) 20:321-330
Raijmakers R, Vogelzangs J, Croxford L, Wesseling P, Venrooij W van, Pruijn G. Citrullination of central nervous system proteins during the development of EAE. J Comp Neurol (2005) 486:243-253.
Marchio S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P., Arap MA, Hajitou A, Ozawa M, Trepel M, Giordano RJ, Nanus DM, Dijkman HBPM, Oosterwijk E, Sidman RL, Cooper MD, Bussolino F, Pasqualini R, Arap W. Aminopeptidase A is a functional target in angiogenic blood vessels.Cancer Cell (2004) 5:151-162
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Jeuken JWM, Deimling A von, Wesseling P. Molecular pathogenesis of oligodendroglial tumors. J Neuro-oncol (2004) 70:161-181.
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