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Matrix biochemistry
P.O. box 9101
6500 HB Nijmegen
The Netherlands
T: +31 24 3616759
F: +31 24 3540339

Dr. van Kuppevelt is a trained biochemist and cell biologist, is associated professor at the Department of Biochemistry and since 2000 is head of the Matrix Biochemistry group. Along side research, he gives biochemistry lectures to (bio)medical students. He is a member of the board of the Dutch Society of Matrix Biology.
Dr. Toin van Kuppevelt

Research focuses on the role of extracellular matrix molecules, notably proteoglycans, in health and disease. Special attention is given to glycosaminoglycans, the sugar moiety of proteoglycans, and their role in renal/lung pathology, and in cancer. In addition, matrix molecules such as collagen, elastin and glycosaminoglycans are used to construct molecularly-defined scaffolds for tissue engineering. The aim is to prepare smart scaffolds to generate specific tissues such as skin, cartilage and blood vessels.

 
Recent key publications

W. F. Daamen, WF., Nillesen, STM., Hafmans, T., Veerkamp, JH., van Luyn, MJA, Van Kuppevelt, TH. (2005).Tissue response of defined collagen-elastin scaffolds in young and adult rats with special attention to calcification. Biomaterials, 26:81-92.

Lensen, JFM., Rops ALWMM, Wijnhoven TJM., Hafmans T., Feitz, WFJ., Oosterwijk E., Banas B., Bindels RJM, van den Heuvel LPWJ., van der Vlag J., Berden JHM., Van Kuppevelt TH. (2005). Localization and functional characterization of glycosaminoglycan domains in the normal human kidney as revealed by phage display-derived single chain antibodies. J. Am. Soc. Nephrol. 16:1279-1288.

Van de Westerlo, EM, Smetsers, TF, Dennissen, MA, Linhardt, RJ, Veerkamp, JH, Van Muijen, GN, Van Kuppevelt, TH. (2002). Human single chains antibodies against heparin: selection, characterization, and effect on coagulation. Blood, 99:2427-2433.

Smetsers, TF., Van de Westerlo, EM., Ten Dam, GB., Clarijs, R., Versteeg, EM., Van Geloof, WL., Veerkamp, JH., Van Muijen, GN., Van Kuppevelt, TH. (2003). Localization and characterization of melanoma-associated glycosaminoglycans: differential expression of chondroitin and heparan sulfate epitopes in melanoma. Cancer Res., 63: 2965-2970.

Jenniskens, GJ., Koopman, WJ., Willems, PHGM., Pecker, I., Veerkamp, JH., Van Kuppevelt, TH. (2003). Phenotypic knock out of heparan sulfates in myotubes impairs excitation-induced calcium spiking. FASEB J., 17: 878-880.

Ten Dam GB, van de Westerlo EM, Smetsers TF, Willemse M, van Muijen GN, Merry CL, Gallagher JT, Kim YS, van Kuppevelt TH (2004). Detection of 2-O-sulfated iduronate and N-acetylglucosamine units in heparan sulfate by an antibody selected against acharan sulfate (IdoA2S-GlcNAc)n. J. Biol. Chem. 279:38346-38352.