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Radiology
6500 HB Nijmegen
T: +31 24 3614795
F: +31 24 3540866

A. Heerschap has a graduate degree in Biochemistry, did his PhD in Biophysical Chemistry on NMR in nucleic acids and worked for Philips Medical Systems before joining the Radiology department on research in Magnetic Resonance. Since 1998 he is full professor at this department and head of the Biomedical MR research group.
Prof. dr. Arend Heerschap

Research is focused on translational research, from in vitro NMR studies of tissues to MR of patients. Fundamental biomedical problems and the advancement of MR as a diagnostic tool are addressed. Main research topics are (1) Energy metabolism in skeletal muscle and brain and (2) Biology, diagnosis and treatment of cancer (prostate, brain, liver, etc). Using transgenic technology, vascular and cellular contrast agents, and natural abundance and labelled spin systems MR is applied in clinical research, diagnostics and in studies of animal models. High resolution and MAS NMR are applied in study of body fluids and biopsies. Dedicated MR systems for research on these objects have been implemented over the years.
 
Recent key publications

Klomp DW, Renema WK, van der Graaf M, de Galan BE, Kentgens AP, Heerschap A. Sensitivity-enhanced (13)C MR spectroscopy of the human brain at 3 Tesla.Magn Reson Med. 2005 Dec 21; [Epub ahead of print]

de Vries IJ, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, Oyen WJ, Bonenkamp JJ, Boezeman JB, Adema GJ, Bulte JW, Scheenen TW, Punt CJ, Heerschap A, Figdor CG. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol. 2005 Nov;23(11):1407-1413. Epub 2005 Oct 30.

van Laarhoven HW, Kaanders JH, Lok J, Peeters WJ, Rijken PF, Wiering B, Ruers TJ, Punt CJ, Heerschap A, van der Kogel AJ. Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer. Int J Radiat Oncol Biol Phys. 2005 Oct 18; [Epub ahead of print].

van Laarhoven HW, de Geus-Oei LF, Wiering B, Lok J, Rijpkema M, Kaanders JH, Krabbe PF, Ruers T, Punt CJ, van der Kogel AJ, Oyen WJ, Heerschap A. Gadopentetate Dimeglumine and FDG Uptake in Liver Metastases of Colorectal Carcinoma as Determined with MR Imaging and PET. Radiology. 2005 Oct;237(1):181-8.

Serlie MJ, de Haan JH, Tack CJ, Verberne HJ, Ackermans MT, Heerschap A, Sauerwein HP. Glycogen synthesis in human gastrocnemius muscle is not representative of whole-body muscle glycogen synthesis. Diabetes. 2005 May;54(5):1277-82.

Kan HE, Buse-Pot TE, Peco R, Isbrandt D, Heerschap A, de Haan A. Lower force and impaired performance during high-intensity electrical stimulation in skeletal muscle of GAMT-deficient knockout mice. Am J Physiol Cell Physiol. 2005 Jul;289(1):C113-9. Epub 2005 Mar 2.