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Dr. Jack A. M. Fransen
Jack Fransen's background is in Cell Biology/ Electron Microscopy. His group has been working on intracellular transport and apical and basolateral sorting of proteins in polarized cells. The group focusses mainly on the ultrastructural aspects using immunoelectron microscopy and confocal techniques. The work has concentrated on the vesicle bound machinery involved in these processes with special emphasis on the function of Rab proteins (i.e. Rab6 isoforms and Rab21) and specific protein tyrosine phosphatases (i.e. PTP-SL) in the regulation of vesicular traffic at the Golgi and post-Golgi level. Recently topic has switched to imaging in space and time of proteins and small molecules involved in localized energy supply in cells.The group also started to implement 3D and 4D imaging within the department and is in charge of a part of the equipment within the Microscopic Imaging Center of the NCMLS (NCMLS-MIC). |
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Recent key publications van Horssen R, Janssen E, Peters W, van de Pasch L, Lindert MM, van Dommelen MM, Linssen PC, Hagen TL, Fransen JA, Wieringa B. Modulation of Cell Motility by Spatial Repositioning of Enzymatic ATP/ADP Exchange Capacity. J Biol Chem 2009; 284:1620-1627. Pluk, H., D. J. Stokes, B. Lich, B. Wieringa, and J. Fransen. 2009. Advantages of indium-tin oxide-coated glass slides in correlative scanning electron microscopy applications of uncoated cultured cells. J. Microsc. 233:353-363. Wanschers B, van de Vorstenbosch R, Wijers M, Wieringa B, King SM, Fransen J. Rab6 family proteins interact with the dynein light chain protein DYNLRB1. Cell Motil Cytoskeleton 2008; 65:183-196. Kuiper JWP, Pluk H, Oerlemans F, van Leeuwen FN, de Lange F, Fransen J, Wieringa B. Creatine Kinase-Mediated ATP Supply Fuels Actin-Based Events in Phagocytosis. PLoS Biol. 2008; 6(3):e51. Willemse M, Janssen E, de Lange F, Wieringa B, Fransen J. ATP and FRET - a cautionary note. Nat. Biotechnol. 2007; 25:170-172. |
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