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Pharmacology &Toxicology

P.O. Box 9101
6500 HB, Nijmegen
The Netherlands
T +31 24 3613654
F +31 24 3614214

Jan Koenderink is assistant professor in biochemical toxicology at the Department of Pharmacology and Toxicology, Radboud University Nijmegen Medical Centre.

Dr. Jan Koenderink

Research interests include molecular interaction of membrane transport proteins and their ligands (substrates and inhibitors). Current projects are focused on the molecular interaction of digitalis-like compounds with the sodium pump (Na,K-ATPase) and multidrug resistance proteins (ABC transporters) (VIDI 2008). In addition the interaction between membrane transporters and novel and existing human drugs, as well as the multidrug resistance transport proteins of the plasmodium parasite are investigated. The studies include the expression of recombinant transport proteins and their biochemical and pharmacodynamic characterization.
 

Recent key publications

De Pont JJ, Swarts HG, Karawajczyk A, Schaftenaar G, Willems PH, Koenderink JB. The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase. Pflugers Arch. 2009 457:623-34.

Russel FG, Koenderink JB, Masereeuw R. Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules. Trends Pharmacol Sci. 2008 29:200-7.

El-Sheikh AA, van den Heuvel JJ, Krieger E, Russel FG, Koenderink JB. Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4). Mol Pharmacol. 2008 74:964-71.

Qiu LY, Krieger E, Schaftenaar G, Swarts HG, Willems PH, De Pont JJ, Koenderink JB. Reconstruction of the complete ouabain-binding pocket of Na,K-ATPase in gastric H,K-ATPase by substitution of only seven amino acids. J Biol Chem. 2005 280:32349-55.

Koenderink JB, Zifarelli G, Qiu LY, Schwarz W, De Pont JJ, Bamberg E, Friedrich T. Na,K-ATPase mutations in familial hemiplegic migraine lead to functional inactivation. Biochim Biophys Acta. 2005 1669:61-8.