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Physiology
P.O. Box 9101
6500 HB, Nijmegen
Geert Grooteplein 28
6525 GA, Nijmegen
T: +31 24 3610580
F: +31 23 3616413

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Joost Hoenderop is Associate Professor of Physiology, has a background in molecular biology and obtained his Ph.D. degree in Medical Sciences at the Radboud University Nijmegen in 2000. Subsequently, he held an EMBO fellowship at the Institute of Pharmacology and Toxicology at the University of Lausanne, Switzerland. He obtained the prestigious ZonMw Vernieuwingsimpuls grant, the Career Program from the Dutch Kidney Foundation and more recently the EURYI award from the European Science Foundation.
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Prof. Dr. Joost Hoenderop
Research interests include the regulation of Ca2+ and Mg2+ transport in epithelia
with a specific focus on the molecular regulation of epithelial Ca2+ and Mg2+ channels (TRPV5&6 and TRPM6&7), members of the transient receptor
potential (TRP) channels. Recent studies indicate that these channels function
as gatekeepers to maintain the extracellular Ca2+ and Mg2+ balance which is
crucial for mammalian development and function. His current work focuses on the
functional aspects of these channels using a comprehensive approach that includes
studies on epithelial cell lines and animal knockout models, identification of
regulatory partners and electrophysiological analysis of channel activity.
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Recent key publications
Thébault S, Cao G, Venselaar H, Xi Q, Bindels RJ, Hoenderop JG. Role of the alpha-kinase domain in transient receptor potential melastatin 6 channel and regulation by intracellular ATP. J Biol Chem 283: 19999-20007, 2008 IF 5,6
Cao G, Thébault S, van der Wijst J, van der Kemp A, Lasonder E, Bindels RJ, Hoenderop JG. RACK1 a new auxiliary protein inhibiting TRPM6 activity via phosphorylation of the fused a-kinase domain. Current Biology 18: 168-176, 2008, IF 10,6
Huybers S, Apostolaki M, van der Eerden BC, Kollias G, Naber TH, Bindels RJ, Hoenderop JG. Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters. Inflamm Bowel Dis 14: 803-811, 2008, IF 4,7
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