      |
|
||||||||
|
Prof. dr. Peter Friedl
Research interest is the visualization of cell-matrix interactions and dynamic cell patterning during immune cell interactions and tumor invasion. We, therefore, use 3D extracellular matrix (ECM) based cell culture models and advanced imaging procedures. Recently, the group moved into in vivo-imaging of tumor and immune cell migration by multiphoton microscopy. This complements in vitro culture technology. These approaches have provided insight into the serial dynamics of T cell scanning across antigen-presenting cells and the diversity of tumor invasion mechanisms, as well as novel escape responses in tumor cell migration.New technology allows imaging deep into tumours (video-interview) |
||||||||
|
Recent key publications Friedl P, den Boer AT, Gunzer M (2005) Tuning immune responses: diversity and adaptation of the immunological synapse. Nat. Rev. Immunol. 5, 532-545. Wolf, K., Wu, Y.I., Liu, Y., Tam, E., Geiger, J., Overall, C., Stack, M.S., Friedl, P. 2007. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat. Cell Biol. 9:893-904. Friedl, P., B. Weigelin. 2008. Interstitial leukocyte migration and immune function. Nat. Immunol. 9:839-848. Andresen, V., S. Alexander, W.-M. Heupel, M. Hirschberg, P. Friedl. 2009. Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr. Opin. Biotechnol. 20:54-62. Friedl, P., D. Gilmour. 2009. Collective cell migration in morphogenesis, regeneration and cancer. Nat. Rev. Mol. Cell Biol. 10:445-457. |
||||||||
