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Prof. Dr. Han G. Brunner
Research interests include the molecular basis of congenital malformations and their implications in understanding developmental processes. Current projects focus on disease gene identification by linkage mapping, and by microarray. In collaboration with researchers at the CMBI, new bioinformatics approaches to the classification of phenotypes and their application to candidate gene identification for multifactorial diseases are developed. |
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Recent key publications van Bokhoven H, Celli J, van Reeuwijk J, Rinne T, Glaudemans B, van Beusekom B, Rieu P, Newbury-Ecob RA, Chiang C, Brunner HG. MYCN haploinsufficiency is associated with reduced brain size and intestinal atresias in Feingold syndrome. Nature Genetics 37:465-467, 2005
De Vries BBA, Pfundt R, Leisink M, Koolen DA, Vissers LELM, Janssen IM, van Reijmersdal S, Nillesen WM, Huys, EHLPG, de Leeuw N, Smeets D, Sistermans EA, Feuth T, van Ravenswaaij-Arts CMA, Geurts van Kessel A, Schoenmakers EFPM, Brunner HG, Veltman JA. Diagnostic genome profiling in mental retardation.Am J Hum Genet. 77:606-616, 2005 Reviews: Brunner HG, Bokhoven H. Genetic players in esophageal atresia and tracheoesophageal fistula. Curr Opin Genet Dev 15:341-347, 2005. Vissers LELM, Veltman JA, Geurts van Kessel A, Brunner HG. Identification of disease genes by whole genome CGH arrays. Hum Mol Genet. 14 Suppl 2:R215-23, 2005. |
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