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  • Dilaver G., van de Vorstenbosch, R., Tarrega, C., Rios, P., Pulido, R., van Aerde, K., Fransen, J. and Hendriks, W. (2007) Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7. FEBS J. 274, 96-108.
  • Shin J.B., Streijger, F., Beynon, A., Peters, T., Gadzala, L., McMillen, D., Bystrom, C., Van der Zee, C.E., Wallimann, T. and Gillespie, P.G. (2007) Hair bundles are specialized for ATP delivery via creatine kinase. Neuron 53, 371-386.
  • van der Heijden G.W., Derijck, A.A., Posfai, E., Giele, M., Pelczar, P., Ramos, L., Wansink, D.G., van der Vlag, J., Peters, A.H. and de Boer, P. (2007) Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation. Nat. Genet. 39, 251-258.
  • Willemse M., Janssen, E., de Lange, F., Wieringa, B. and Fransen, J. (2007) ATP and FRET--a cautionary note. Nat. Biotechnol. 25, 170-172.
  • Chirivi, R.G., Noordman, Y.E., Zee, C.E. and Hendriks W.J. (2007) Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice. J. Neurochem. 101, 829-840.
  • Renema W.K., Kan, H.E., Wieringa, B. and Heerschap, A. (2007) In vivo magnetic resonance spectroscopy of transgenic mouse models with altered high-energy phosphoryl transfer metabolism. NMR Biomed. 20, 448-467.
  • Wanschers, B., van de Vorstenbosch, R., Schlager, M.A., Splinter, D., Akhmanova, A., Hoogenraad, C., Wieringa, B. and Fransen, J. (2007) A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells. Exp. Cell Res. In Press.
 
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  • van den Broek, W.J., Nelen, M.R., van der Heijden, G.W., Wansink, D.G. and Wieringa, B. (2006) Fen 1 does not control somatic hypermutability of the (CTG)(n)*(CAG)(n) repeat in a knock-in mouse model for DM1. FEBS Lett. 580, 5208-5214.
  • Van Herpen, R.E., Tjeertes, J.V., Mulders, S.A., Oude Ophuis, R.J., Wieringa, B. and Wansink, D.G. (2006) Coiled-coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms. FEBS J. 273, 1124-1136.
  • Wansink, D.G., van Herpen, R.E.M.A. and Wieringa, B. Normal and Pathophysiological Significance of Myotonic Dystrophy Protein Kinase. Genetic Instabilities and Neurological Diseases Chapter 5, 79-97. Acad. Press R.D. Wells & Ashizawa T.eds.
  • Hancock, C.R., Janssen, E. and Terjung, R.L. (2006) Contraction-mediated phosphorylation of AMPK is lower in skeletal muscle of adenylate kinase-deficient mice. J. Appl. Physiol. 100, 406-413.
  • Pellinen, T., Arjonen, A., Vuoriluoto, K., Kallio, K., Fransen, J. A., and Ivaska, J. (2006). Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of {beta}1-integrins. J. Cell Biol. 173, 767-780.
  • Cambi, A., Joosten, B., Koopman, M., de Lange, F., Beeren, I., Torensma, R., Fransen, J. A., Garcia-Parajo, M., van Leeuwen, F. N., and Figdor, C. G. (2006). Organization of the Integrin LFA-1 in Nanoclusters Regulates Its Activity. Mol. Biol. Cell 17, 4270-4281.
  • de Bruijn, D.R., Allander, S.V., van Dijk, A.H., Willemse, M.P., Thijssen, J., van Groningen, J.J., Meltzer, P.S. and Geurts van Kessel, A. (2006) The Synovial Sarcoma-Associated SS18-SSX2 Fusion Protein Induces Epigenetic Gene (De)Regulation. Cancer Res. 66, 9474-9482.
  • de Bruijn, D.R., Peters, W.J., Chuva de Sousa Lopes, S.M., van Dijk, A.H., Willemse, M.P., Pfundt, R., de Boer, P. and Geurts van Kessel, A. (2006) Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression. Hum. Mol. Genet. 15, 2936-2944.
  • Noordman, Y.E., Jansen, P.A.M. and Hendriks, W.J.A.J. (2006) Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells. J. Mol. Signal. 1: 4.
   
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  • van Ham M., Kemperman, L., Wijers, M., Fransen, J. and Hendriks, W. (2005) Subcellular Localization and Differentiation-Induced Redistribution of the Protein Tyrosine Phosphatase PTP-BL in Neuroblastoma Cells. Cell. Mol. Neurobiol. 25,1225-1244.
  • van den Berk, L.C., Landi, E., Harmsen, E., Dente, L. and Hendriks, W.J. (2005) Redox-regulated affinity of the third PDZ domain in the phosphotyrosine phosphatase PTP-BL for cysteine-containing target peptides. FEBS J. 272, 3306-3316.
  • Lorber, B., Hendriks, W.J., Van der Zee, C.E., Berry, M. and Logan, A. (2005) Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury. Eur. J. Neurosci. 21, 2375-2383.
  • Tárrega, C., Ríos, P., Cejudo-Marín, R., Blanco-Aparicio, C., van den Berk, L., Schepens, J., Hendriks, W., Tabernero, L. and Pulido, R . (2005) ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1. J. Biol. Chem. 280, 37885-37894.
  • Hancock, C.R., Janssen, E. and Terjung, R.L. (2005) Skeletal muscle contractile performance and ADP accumulation in adenylate kinase-deficient mice. Am. J. Physiol. Cell Physiol. 288, C1287-C1297.
  • Streijger, F., Oerlemans, F., Ellenbroek, B.A., Jost, C.R., Wieringa, B. and Van der Zee, C.E. (2005) Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit. Behav. Brain Res. 157, 219-234.
  • van Herpen, R.E., Oude Ophuis, R.J., Wijers, M., Bennink, M.B., van de Loo, F.A., Fransen, J., Wieringa, B. and Wansink, D.G. (2005) Divergent mitochondrial and endoplasmic reticulum association of DMPK splice isoforms depends on unique sequence arrangements in tail anchors. Mol. Cell. Biol. 25, 1402-1414.
  • Klivenyi, P., Calingasan, N.Y., Starkov, A., Stavrovskaya, I.G., Kristal, B.S., Yang, L, Wieringa, B. and Beal M.F. (2005) Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase. Neurobiol. Dis. 15, 610-617.
  • Eleveld-Trancikova, D., Triantis, V., Moulin, V., Looman, M.W., Wijers, M., Fransen, J.A., Lemckert, A.A., Havenga, M.J., Figdor, C.G., Janssen, R.A. and Adema G.J. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. J. Leukoc. Biol. 2005; 77, 337-343.
  • Smits, B.M., Peters, T.A., Mul, J.D., Croes, H.J., Fransen, J.A., Beynon, A.J., Guryev, V., Plasterk, R.H. and Cuppen, E. (2005) Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics. Genetics 170,1887-1896.

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  • Dzeja, P.P., Terzic A. and Wieringa, B. (2004) Phosphotransfer dynamics in skeletal muscle from Creatine kinase gene-deleted mice. Mol.Cell.Biochem. 256, 13-27.
  • Streijger F., Jost, C.R., Oerlemans, F., Ellenbroek, B. A., Cools, A.R., Wieringa, B. and Van der Zee, I. (2004) Mice lacking the UbCKmit isoform of creatine kinase reveal slower spatial learning acquisition, diminished exploration and habituation, and reduced acoustic startle reflex responses.Mol.Cell.Biochem. 256, 305-318.
  • Janssen E., Kuiper, J., Hodgson, D., Zingman, L.V., Alekseev, A.E., Terzic, A. and Wieringa, B. (2004) Two structurally distinct and spatially compartmentalized Adenylate kinases are expressed from the AK1 gene in mouse brain. Mol.Cell.Biochem. 256, 59-72.
  • De Bruin W, Oerlemans F and Wieringa B. (2004) Adenylate kinase I does not affect cellular growth characteristics under normal and metabolic stress conditions. Exp. Cell. Res. 297, 97-107.
  • La Spada A, Richards R.I, and Wieringa B. (2004) Dynamic mutations on the move in Banff. Nature Genet. 36, 667-670.
  • In 't Zandt H., J., A., Renema W., K.J., Streijger, F., Jost, C., Klomp, D.W.J., Oerlemans, F., van der Zee, C.E.E.M., Wieringa, B. and Heerschap, A. (2004) Cerebral Creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: A quantitative in vivo 1H and 31P magnetic resonance study. J. Neurochem. 90, 1321-1330.
  • O'Cochlain, D.F., Perez-Terzic, C., Reyes, S., Kane, G.C., Behfar, A, Hodgson, D.M., Strommen, J.A., Liu, X-K, Van den Broek, W., Wansink, D.G., Wieringa, B. and Terzic, A. (2004) Transgenic Overexpression of Human DMPK Accumulates into Hypertrophic Cardiomyopathy, Myotonic Myopathy and Hypotension Traits of Myotonic Dystrophy. Hum.Mol.Genet. 13, 2505-2518.
  • Simpson, J. C., Griffiths, G., Wessling-Resnick, M., Fransen, J. A., Bennett, H., and Jones, A. T. (2004). A role for the small GTPase Rab21 in the early endocytic pathway. J Cell Sci 117, 6297-6311.
  • Chirivi, R. G., Dilaver, G., van de Vorstenbosch, R., Wanschers, B., Schepens, J., Croes, H., Fransen, J., and Hendriks, W. (2004). Characterization of multiple transcripts and isoforms derived from the mouse protein tyrosine phosphatase gene Ptprr. Genes Cells 9, 919-33.
  • Cambi, A., de Lange, F., van Maarseveen, N. M., Nijhuis, M., Joosten, B., van Dijk, E. M. H. P., de Bakker, B. I., Fransen, J. A. M., Bovee-Geurts, P. H. M., van Leeuwen, F. N., Van Hulst, N. F., and Figdor, C. G. (2004). Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells. J. Cell Biol. 164, 145-155.
  • Wansink, D.G., Peters, W., Schaafsma, I., Sutmuller, R.P.M., Oerlemans, F., Adema, G.J., Wieringa, B., Van der Zee, C.E.E.M., Hendriks, W.J.A.J. (2004) Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity. Physiol. Genom., 19, 50-60.
  • Kolkman, M.J.M., Streijger, F., Linkels, M., Bloemen, M., Heeren, D., Hendriks, W.J.A.J., Van der Zee, C.E.E.M. (2004) Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests. Behav. Brain Res. 154, 171-182.
  • Kubosaki, A, Gross, S, Miura, J, Saeki, K, Zhu, M, Nakamura, S, Hendriks, W & Notkins, AL (2004) Targeted Disruption of the IA-2? Gene Causes Glucose Intolerance and Impairs Insulin Secretion but Does Not Prevent the Development of Diabetes in NOD Mice. Diabetes 53: 1684-1691.
  • Lorber, B, Berry, M, Hendriks, W, den Hertog, J, Pulido, R & Logan, A (2004) Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTP?, STEP and LAR. Mol. Cell. Neurosci. 27: 404-416.
  • Walma, T, Aelen, J, Nabuurs, S, Oostendorp, M, van den Berk, L, Hendriks, W & Vuister, GW (2004) A closed binding pocket and global destabilization modify the binding properties of an alternatively spliced form of the second PDZ domain of PTP-BL. Structure 12: 11-20.

  • van den Berk, L, van Ham, M, te Lindert, MM, Walma, T, Aelen, J, Vuister, GW & Hendriks, WJAJ (2004) The interaction of PTP-BL PDZ domains with RIL: An enigmatic role for the RIL LIM domain. Mol. Biol. Rep. 31: 203-215.

  • de Groof A, Lim Y, Gilkerson R, Bhattacharjee M, Figurski D, Schon E (2004) Exploring the use of the bacterial conjugation system to deliver DNA to mitochondria. Biochemica et Biophysica Acta-Bioenergetics 1657: 25-25 Suppl. 1

  • Zimmerman AW, Nelissen JM, van Emst-de Vries SE, Willems PH, de Lange F, Collard JG, van Leeuwen FN, Figdor CG (2004) Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases. J Cell Sci 117:2841-2852

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  • In 't Zandt H.J.A., de Groof A.J.C., Renema W.K.J., Oerlemans F.T.J.J., Klomp, D.W.J., Wieringa B. and Heerschap A. (2003) Presence of (phospho)creatine in developing and adult skeletal muscle of mice without mitochondrial and cytosolic muscle Creatine kinase isoforms. J. Physiol. 548, 847-858.
  • Renema W.K.J., Klomp D.W.J., Philippens MEP, van den Bergh AJ, Wieringa B and Heerschap A (2003). Magnetization transfer effect on the Creatine methyl resonance studied by CW off-resonance irradiation in human skeletal muscle on a clinical MR system. Magnetic-Resonance-In-Medicine 50, 468-473.
  • Wansink D.G., van Herpen R.E.M.A., Coerwinkel-Driessen M.M., Groenen P.J.T.A., Hemmings B.A. and Wieringa B. (2003) Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization. Mol.Cell.Biol. 23, 5489-5501.
  • Janssen E., de Groof A, Wijers M, Fransen J, Dzeja P.P., Terzic A. and Wieringa, B. (2003). Adenylate kinase I deficiency induces molecular and structural adaptations to support muscle energy metabolism. J.Biol.Chem. 278, 12937-12945.
  • Janssen E, Wieringa B, Terzic A. and Dzeja P.P. (2003) Impaired intracellular energetic communication in muscles of mice with combined Creatine kinase and adenylate kinase (M-CK/AK1) deficiency. J.Biol.Chem. 278(33): 30441-30449.
  • Renema W.K.J., Schmidt A, van Asten J.J.A., Oerlemans F., Ullrich K, Wieringa B., Isbrandt D., Heerschap A. (2003) MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: Validation of an animal model to study Creatine deficiency. Magnetic-Resonance-In-Medicine 50, 936-943.
  • Wansink D.G. and Wieringa, B. (2003) Transgenic mouse models for myotonic dystrophy type 1 (DM1). Cytogenet. Genome Res. 100, 230-242.
  • Schulz, P.E., McIntosh, A.D., Kasten, M.R., Wieringa, B. and Epstein, H.F. (2003) A role for myotonic dystrophy protein kinase in synaptic plasticity. J.Neurophysiology 89, 1177-1186.
  • Westerlaken, J.H., Van der Zee, C.E., Peters, W. and Wieringa, B. (2003) The DMWD protein from the myotonic dystrophy (DM1) gene region is developmentally regulated and is present most prominently in synapse-dense brain areas. Brain Res. 971, 116-127.
  • van Ham, M., Croes, H., Schepens, J., Fransen, J., Wieringa, B., and Hendriks, W. (2003) Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. Genes to Cells 8, 631-644.
  • Katz, A., Andersson, D.C., Yu, J., Norman, B., Sandström, M.E., Wieringa, B. and Westerblad, H. (2003) Contraction-mediated glycogenolysis in mouse skeletal muscle lacking Creatine kinase: role of phosphorylase b activation. J. Physiol. 553, 523-531.
  • Wansink, D.G. and Wieringa, B. (2003). Myotonic Dystrophy Type I: a complex multisystemic manifestation related to an instable (CTG)n repeat in the DMPK gene. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. D. Ganten and K. Ruckpaul, Eds.
  • Dilaver, G., Schepens, J., van den Maagdenberg, A., Wijers, M., Pepers, B., Fransen, J. and Hendriks, W. (2003) Colocalisation of the protein tyrosine phosphatases PTP-SL and PTPBR7 with ß4-adaptin in neuronal cells. Histochem. Cell Biol. 119, 1-13.
  • Drake, PG, Peters, GH, Andersen, HS, Hendriks, W & Møller, NPH (2003) A novel strategy for the development of selective active site inhibitors of the protein tyrosine phosphatase-like proteins IA-2 and IA-2ß. Biochem. J. 373: 393-401.
  • van der Zee, CEEM, Man, TY, van Lieshout, EMM, van der Heijden, I, van Bree, M & Hendriks, WJAJ (2003) Delayed peripheral nerve regeneration and central nervous system collateral sprouting in leukocyte common antigen-related protein tyrosine phosphatase deficient mice. Eur. J. Neurosci. 17: 991-1005.
  • van Ham, M & Hendriks, W (2003) PDZ domains - glue and guide. Mol. Biol. Rep. 30: 69-82.
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  • van den Broek, W., Nelen, M.R., Wansink, D.G., Coerwinkel, M., te Riele, H., Groenen, P.J.T.A. and Wieringa, B. (2002). Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins. Hum. Mol. Genet. 11, 191-198.
  • Jost, C.R., C.E.E.M. Van der Zee, H.J.A. in 't Zandt, F. Oerlemans, M. Verheij, F. Streijger, Fransen, J., Heerschap, A., Cools, A.R. and Wieringa B. (2002). Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. Eur J Neurosci 15,1692-1706.
  • Verbeek, M.M., Otte-Höller, I., Fransen, J.A.M. and R.M.W. de Waal (2002). Accumulation of the Amyloid-ß Precursor Protein in Multivesicular Body-like Organelles. J Histochem Cytochem 50,681-690.
  • Engering, A., Geijtenbeek, T.B.H., van Vliet, S.J., Wijers, M., van Liempt, E., Demaurex, N., Lanzavecchia, A., Fransen, J., Figdor, C.G., Piguet, V. and van Kooyk Y. (2002). The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J Immunol 168,2118-2126.
  • de Groof, A.J.C., Fransen, J.A.M., Errington, R.J., Willems, P.H.G.M., Wieringa, B. and Koopman, W.J.H. (2002). The creatine kinase system is essential for optimal refill of the sarcoplasmic reticulum Ca2+ store in skeletal muscle. J Biol Chem 277,5275-84
  • Pucar D, Bast P, Gumina RJ, Lim L, Drahl C, Juranic N, Macura S, Janssen E, Wieringa B, Terzic A and Dzeja PP. (2002). Adenylate kinase AK1 knockout heart: Energetics and functional performance under ischemia-reperfusion. Am.J.Physiol. Heart Circ. Physiol 283, H776-H782.
  • Makarchikov, A.F., Wins, P., Janssen, E., Wieringa, B., Grisar, T. and Bettendorf, L. (2002) Adenylate kinase I knockout mice have normal thiamine triphosphate levels. Biochim. Biophys. Acta. 1592, 117-121.
  • In 't Zandt H.J.A., de Groof A.J.C., Renema W.K.J., Oerlemans F.T.J.J., Klomp, D.W.J., Wieringa B. and Heerschap A. (2003) Presence of (phospho)Creatine in developing and adult skeletal muscle of mice without mitochondrial and cytosolic muscle Creatine kinase isoforms. J. Physiol. 548, 847-858.
  • Van der Zee, C.E.E.M. and Hagg, T. (2002) Delayed NGF infusion fails to reverse axotomy-induced degeneration of basal forebrain cholinergic neurons in adult p75LNTR-deficient mice. Neuroscience 110, 641-651.
  • Gross, S., Blanchetot, C., Schepens, J., Albet, S., Lammers, R., den Hertog, J., and Hendriks, W. (2002) Multimerization of the Protein-tyrosine Phosphatase (PTP)-like Insulin-dependent Diabetes Mellitus Autoantigens IA-2 and IA-2beta with Receptor PTPs (RPTPs): Inhibition of RPTPa enzymatic activity. J. Biol. Chem. 277, 48139-48145.
  • Walma, T., Spronk, C. A. E. M., Tessari, M., Aelen, J., Schepens, J., Hendriks, W., and Vuister, G. W. (2002) Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL. J. Mol. Biol. 316, 1101-1110.
  • Zeeuwen, P. L., van Vlijmen-Willems, I. M., Hendriks, W., Merkx, G. F., and Schalkwijk, J. (2002) A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification. Hum. Mol. Genet. 11, 2867-2875.
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  • Carrasco, A. J., Dzeja, P. P., Alekseev, A. E., Pucar, D., Zingman, L. V., Abraham, M. R., Hodgson, D., Bienengraeber, M., Puceat, M., Janssen, E., Wieringa, B. and Terzic, A. (2001). Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels. Proc Natl Acad Sci USA 98, 7623-8.
  • de Groof, A. J., Smeets, B., Groot Koerkamp, M. J., Mul, A. N., Janssen, E. E., Tabak, H. F. and Wieringa, B. (2001). Changes in mRNA expression profile underlie phenotypic adaptations in creatine kinase-deficient muscles. FEBS Lett 506, 73-8.
  • de Groof, A. J., Oerlemans, F. T., Jost, C. R. and Wieringa, B. (2001). Changes in glycolytic network and mitochondrial design in creatine kinase-deficient muscles. Muscle Nerve 24, 1188-96.
  • Kekelidze, T., Khait, I., Togliatti, A., Benzecry, J. M., Wieringa, B. and Holtzman, D. (2001). Altered brain phosphocreatine and ATP regulation when mitochondrial creatine kinase is absent. J Neurosci Res 66, 866-72.
  • Slimane, T. A., Lenoir, C., Bello, V., Delaunay, J. L., Goding, J. W., Chwetzoff, S., Maurice, M., Fransen, J. A. and Trugnan, G. (2001). The cytoplasmic/transmembrane domain of dipeptidyl peptidase IV, a type II glycoprotein, contains an apical targeting signal that does not specifically interact with lipid rafts. Exp Cell Res 270, 45-55.
  • Terszowski, G., Jankowski, A., Hendriks, W. J., Rolink, A. G. and Kisielow, P. (2001). Within the hemopoietic system, LAR phosphatase is a T cell lineage-specific adhesion receptor-like protein whose phosphatase activity appears dispensable for T cell development, repertoire selection and function. Eur J Immunol 31, 832-40.
  • Van Lieshout, E. M., Van der Heijden, I., Hendriks, W. J. and Van der Zee, C. E. (2001). A decrease in size and number of basal forebrain cholinergic neurons is paralleled by diminished hippocampal cholinergic innervation in mice lacking leukocyte common antigen-related protein tyrosine phosphatase activity. Neuroscience 102, 833-41.