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Objectives of
the Network:
The identification of IA-2 and IA-2b, two homologous tyrosine phosphatase-like
(PTP-like) transmembrane molecules, as major autoantigens in Type 1
(insulin-dependent) diabetes mellitus greatly facilitated preclinical
diagnosis of this major disease. IA-2 and IA-2b are present within the
secretory granule membrane of pancreatic islets and neuroendocrine cells
suggesting that their physiological roles could have bearing for defective
secretory responses such as those occurring in Type 2 diabetes as well.
The Network set out to study the roles of IA-2 and IA-2b in the development
and secretory function of the pancreatic beta cell.
Roles of the Participating Teams:
Next to the direct assessment of IA-2 / IA-2b expression modulation
and their influence on insulin secretion in pancreatic islet cells (Partners
2, 3), the effects of the cell biology of IA-2 and IA-2b interactions
with other proteins (Partners 1, 2, 4) and the identification of biomolecules
(Partners 1-5) and small compounds that may modulate IA-2 and IA-2b
activity (Partner 5) have been undertaken.
Please
click here for a full version (PDF) of the Networks Summary Report
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