Assistant Professor:

Van der Zee, Catharina E.E.M.,
Ph.D. October 16, 1958.
Duties: 0.8 research, 0.2 teaching

Tel. +31243614296/3614329 Fax. +31.24.3615317
E-mail: i.vanderzee@ncmls.ru.nl
Dr. Catharina Van der Zee studied Biology and specialized in Molecular Neurobiology and Biomedical Sciences including physiology, anatomy/histology and behavior. During the last 15 years, studies have been focussed on experimental sprouting models in rodents: peripheral nerve regeneration, peripheral neuropathies, kindling-induced mossy fiber sprouting, and collateral sprouting of the basal forebrain cholinergic system. In addition, research directed to plasticity of the brain (related to Alzheimer's disease) emphasized on the role of neurotrophins and neurotrophin receptors. Recently, the impact of LAR protein tyrosine phosphatase deficiency is studied in two mouse models of PNS and CNS axonal outgrowth. Currently, a standardized behavioral test battery for the analysis of cognitive, emotional, social, and motor behavior of transgenic and knockout mice is being validated and extended (in collaboration with Prof. A. Cools, psychoneuropharmacology, Ms. F. Streijger, Cell Biology, and the Animal Care Facility). The biological and behavioral consequences of Brain Creatine Kinase deficiency in mice demonstrated for instance impaired spatial learning and habituation, and age-related cognitive defects compared to wildtype control animals. Observations relating to aggressive behavior, nest building, and anxiety are studied as well. The behavioral facility data are combined with a histological/anatomical analysis of the transgenic and knockout mice to unravel phenotypical changes, especially in the brain.
  • Chirivi, R.G., Noordman, Y.E., Zee, C.E. and Hendriks W.J. (2007) Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice. J. Neurochem. 101, 829-840.
  • Shin J.B., Streijger, F., Beynon, A., Peters, T., Gadzala, L., McMillen, D., Bystrom, C., Van der Zee, C.E., Wallimann, T. and Gillespie, P.G. (2007) Hair bundles are specialized for ATP delivery via creatine kinase. Neuron 53, 371-386.
  • Lorber, B., Hendriks, W.J., Van der Zee, C.E., Berry, M. and Logan, A. (2005) Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury. Eur. J. Neurosci. 21, 2375-2383.
  • Streijger F., Jost, C.R., Oerlemans, F., Ellenbroek, B. A., Cools, A.R., Wieringa, B. and Van der Zee, I. (2004) Mice lacking the UbCKmit isoform of creatine kinase reveal slower spatial learning acquisition, diminished exploration and habituation, and reduced acoustic startle reflex responses. . Mol.Cell.Biochem. 256, 305-318.
  • In 't Zandt H., J., A., Renema W., K.J., Streijger, F., Jost, C., Klomp, D.W.J., Oerlemans, F., van der Zee, C.E.E.M., Wieringa, B. and Heerschap, A. (2004) Cerebral Creatine kinase deficiency influences metabolite levels and morphology in the mouse brain: A quantitative in vivo 1H and 31P magnetic resonance study. J. Neurochem. 90, 1321-1330.
  • Wansink, D.G., Peters, W., Schaafsma, I., Sutmuller, R.P.M., Oerlemans, F., Adema, G.J., Wieringa, B., Van der Zee, C.E.E.M., Hendriks, W.J.A.J. (2004) Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity. Physiol. Genom., 19, 50-60.
  • Kolkman, M.J.M., Streijger, F., Linkels, M., Bloemen, M., Heeren, D., Hendriks, W.J.A.J., Van der Zee, C.E.E.M. (2004) Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests. Behav. Brain Res. 154, 171-182.
  • Westerlaken, J.H.A.M., Van der Zee, C.E.E.M., Peters, W., Wieringa, B. (2003) The DMWD protein from the Myotonic Dystrophy (DM1) gene region is developmentally regulated and is present most prominently in synapse-dense brain areas. Brain Res. 971,116-127.
  • Van der Zee, C.E.E.M. and Hagg, T. (2002) Delayed NGF infusion fails to reverse axotomy-induced degeneration of basal forebrain cholinergic neurons in adult p75LNTR-deficient mice. Neuroscience 110, 641-651.
  • Jost, C., Van der Zee, C.E.E.M., In 't Zandt, H.J.A., Oerlemans, F., Verheij, M., Streijger, F., Fransen, J., Heerschap, A., Cools, A.R. and Wieringa, B. (2002) Creatine kinase B driven energy transfer in brain is important for habituation and spatial learning behavior, mossy fiber field size, and determination of seizure susceptibility. Eur. J. Neurosci 15,1692-1706.
  • In 't Zandt, H.J.A., Jost, C., Klomp, D.W.J., Oerlemans, F., Van der Zee, C.E.E.M., Wieringa, B. and Heerschap, A. (2002) Quantitative 1H and 31P MR-spectroscopy and -imaging reveal changes in metabolite levels and morphology of creatine kinase (CK)-deficient mouse brain. J. Neurochem., submitted.
  • Van Lieshout, E.M.M., Van der Heijden, I., Hendriks, W.J.A.J. and Van der Zee, C.E.E.M. (2001) A decrease in size and number of basal forebrain cholinergic neurons is paralleled by diminished hippocampal cholinergic innervation in mice lacking leukocyte common antigen-related protein tyrosine phosphatase activity. Neuroscience, 102, 833-841.
  • Van der Zee, C.E.E.M., Streijger, F., Jost, C., Oerlemans, F., Sluyter, F., Wieringa, B., Verheij, M. and Cools, A.R. (2001) Brain creatine kinase-deficient mice show impaired spatial learning, less habituation and nestbuilding, but increased aggressive behavior. Behav. Pharmacol. 12 (Suppl. 1), S105.
  • Van der Zee, C.E.E.M., Man, T.Y., Van der Heijden, I., Van Lieshout, E.M.M. and Hendriks, W.J.A.J. (2000) LAR protein tyrosine phosphatase deficient mice show a delay in PNS sensory nerve regeneration and CNS cholinergic collateral sprouting. Eur. J. Neurosci. 12 (Suppl. 11), 290.
  • Klootwijk, R., Franke, B., Van der Zee, C.E.E.M., de Boer, R.T., Wilms, W., Hol, F.A. and Mariman, E.C. (2000) A deletion encompassing Zic3 in bent tail, a mouse model for X-linked neural tube defects. Human Mol. Genetics 9, 1615-1622.
  • Kramer, B.M.R., Van der Zee, C.E.E.M. and Hagg, T. (1999) p75 nerve growth factor receptor is important for retrograde transport of neurotrophins in adult cholinergic basal forebrain neurons. Neuroscience 94, 1163-1172.
  • Adams, B., Sazgar, M., Osehobo, P., Van der Zee, C.E.E.M., Diamond, J., Fahnestock, M. and Racine, R.J. (1997) Nerve growth factor accelerates seizure development, enhances mossy fiber sprouting, and attenuates seizure-induced decreases in neuronal density in the kindling model of epilepsy. J. Neurosci. 17, 5288-5296.
  • Van der Zee, C.E.E.M., Lourenssen, S., Stanisz, J. and Diamond, J. (1995a) NGF deprivation of adult rat brain results in cholinergic hypofunction and selective impairments in spatial learning. Eur. J. Neurosci. 7, 160-168.
  • Van der Zee, C.E.E.M., Rashid, K., Le K., Moore K.-A., Stanisz, J., Diamond, J., Racine, R.J. and Fahnestock, M. (1995b) Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats. J. Neurosci. 15, 5316-5323.
  • Rashid, K., Van der Zee, C.E.E.M., Ross, G., Chapman, C.A., Stanisz, J., Diamond, J., Racine, R.J. and Fahnestock, M. (1995) A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy. Proc. Natl. Acad. Sci. USA 92, 9495-9499.
  • Van der Zee, C.E.E.M., Fawcett, J. and Diamond, J. (1992) Antibody to NGF inhibits collateral sprouting of septohippocampal fibers following entorhinal cortex lesion in adult rats. J. Comp. Neurol. 326, 91-100.
  • Van der Zee, C.E.E.M., Brakkee, J.H. and Gispen, W.H. (1991) Putative neurotrophic factors and functional recovery from peripheral nerve damage in the rat. Br. J. Pharmacol. 103, 1041-1046.
  • Van der Zee, C.E.E.M., Nielander, H.B., Vos, J.P., Lopes da Silva, S., Verhaagen, J., Oestreicher, B., Schrama, L., Schotman, P. and Gispen, W.H. (1989) Expression of growth-associated protein B-50 (GAP-43) in dorsal root ganglia and sciatic nerve during regenerative sprouting. J. Neurosci. 9, 3505- 3512.
  • Van der Zee, C.E.E.M., Gerritsen van der Hoop, R. and Gispen, W.H. (1989) Beneficial effect of Org 2766 in treatment of peripheral neuropathy in streptozocin-induced diabetic rats. Diabetes 38, 225-230.
  • Synergy program UMC St. Radboud / KUN, FMW (CEEM Van der Zee)
  • Innovation Grant 2000-01 UMC St. Radboud / KUN, FMW: Set-up and validation of a brain research facility for genetically-modified mice: behavioral, cognitive, and histological-anatomical analysis (CEEM Van der Zee, AR Cools, 1 technician)