Associate Professor:

Wiljan Hendriks, Ph.D.
October 7, 1959.
Duties: 0.9 research, 0.1 teaching

Tel. +31.24.3614334
Fax. +31.24.3615317
E-mail w.hendriks@ncmls.ru.nl

Wiljan Hendriks' background is in biochemistry/molecular biology. For a number of years now, his group has been working on the cell biological role of various protein tyrosine phosphatases (PTPs), all of which are expressed in neuronal tissues. Work has concentrated on the functional aspects and biological role of these PTPs and the group has extensive experience in a wide variety of molecular biological and molecular genetic techniques including in situ hybridization (insitu.jpg), gene knock-out technology (larwho.jpg), cell culture and transfection techniques and yeast two-hybrid methodology.
  • Chirivi, R.G., Noordman, Y.E., Zee, C.E. and Hendriks W.J. (2007) Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice. J. Neurochem. 101, 829-840.
  • Dilaver G., van de Vorstenbosch, R., Tarrega, C., Rios, P., Pulido, R., van Aerde, K., Fransen, J. and Hendriks, W. (2007) Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7. FEBS J. 274, 96-108.
  • Noordman, Y.E., Jansen, P.A.M. and Hendriks, W.J.A.J. (2006) Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells. J. Mol. Signal. 1: 4.
  • Tárrega, C., Ríos, P., Cejudo-Marín, R., Blanco-Aparicio, C., van den Berk, L., Schepens, J., Hendriks, W., Tabernero, L. and Pulido, R . (2005) ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1. J. Biol. Chem. 280, 37885-37894.
  • Lorber, B., Hendriks, W.J., Van der Zee, C.E., Berry, M. and Logan, A. (2005) Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury. Eur. J. Neurosci. 21, 2375-2383.
  • van den Berk, L.C., Landi, E., Harmsen, E., Dente, L. and Hendriks, W.J. (2005) Redox-regulated affinity of the third PDZ domain in the phosphotyrosine phosphatase PTP-BL for cysteine-containing target peptides. FEBS J. 272, 3306-3316.
  • van Ham M., Kemperman, L., Wijers, M., Fransen, J. and Hendriks, W. (2005) Subcellular Localization and Differentiation-Induced Redistribution of the Protein Tyrosine Phosphatase PTP-BL in Neuroblastoma Cells. Cell. Mol. Neurobiol. 25,1225-1244.
  • Chirivi, R. G., Dilaver, G., van de Vorstenbosch, R., Wanschers, B., Schepens, J., Croes, H., Fransen, J., and Hendriks, W. (2004). Characterization of multiple transcripts and isoforms derived from the mouse protein tyrosine phosphatase gene Ptprr. Genes Cells 9, 919-33.
  • Wansink, D.G., Peters, W., Schaafsma, I., Sutmuller, R.P.M., Oerlemans, F., Adema, G.J., Wieringa, B., Van der Zee, C.E.E.M., Hendriks, W.J.A.J. (2004) Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity. Physiol. Genom., 19, 50-60.
  • Kolkman, M.J.M., Streijger, F., Linkels, M., Bloemen, M., Heeren, D., Hendriks, W.J.A.J., Van der Zee, C.E.E.M. (2004) Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests. Behav. Brain Res. 154, 171-182.
  • Kubosaki, A, Gross, S, Miura, J, Saeki, K, Zhu, M, Nakamura, S, Hendriks, W & Notkins, AL (2004) Targeted Disruption of the IA-2? Gene Causes Glucose Intolerance and Impairs Insulin Secretion but Does Not Prevent the Development of Diabetes in NOD Mice. Diabetes 53: 1684-1691.
  • Lorber, B, Berry, M, Hendriks, W, den Hertog, J, Pulido, R & Logan, A (2004) Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTP?, STEP and LAR. Mol. Cell. Neurosci. 27: 404-416.
  • Walma, T, Aelen, J, Nabuurs, S, Oostendorp, M, van den Berk, L, Hendriks, W & Vuister, GW (2004) A closed binding pocket and global destabilization modify the binding properties of an alternatively spliced form of the second PDZ domain of PTP-BL. Structure 12: 11-20
  • van den Berk, L, van Ham, M, te Lindert, MM, Walma, T, Aelen, J, Vuister, GW & Hendriks, WJAJ (2004) The interaction of PTP-BL PDZ domains with RIL: An enigmatic role for the RIL LIM domain. Mol. Biol. Rep. 31: 203-215.
  • Dilaver, G., Schepens, J., van den Maagdenberg, A., Wijers, M., Pepers, B., Fransen, J. and Hendriks, W. (2003). Colocalisation of the protein tyrosine phosphatases PTP-SL and PTPBR7 with ß4-adaptin in neuronal cells. Histochem. Cell Biol. 119,1-13.
  • Gross, S., Blanchetot, C., Schepens, J., Albet, S., Lammers, R., den Hertog, J., and Hendriks, W. (2002) Multimerization of the Protein-tyrosine Phosphatase (PTP)-like Insulin-dependent Diabetes Mellitus Autoantigens IA-2 and IA-2beta with Receptor PTPs (RPTPs): Inhibition of RPTPa enzymatic activity. J. Biol. Chem. 277, 48139-48145
  • Zeeuwen, P. L., van Vlijmen-Willems, I. M., Hendriks, W., Merkx, G. F., and Schalkwijk, J. (2002) A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification. Hum. Mol. Genet. 11, 2867-2875
  • Walma, T., Spronk, C.A.E.M., Tessari, M., Aelen, J., Schepens, J., Hendriks, W. and Vuister, G.W.: Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL. J. Mol. Biol. 316 (2002) 1101-1110.
  • Van Lieshout, E.M.M., Van der Heijden, I., Hendriks, W.J.A.J. and Van der Zee, C.E.E.M.: A decrease in size and number of basal forebrain cholinergic neurons is paralleled by diminished hippocampal cholinergic innervation in mice lacking Leukocyte Common Antigen-Related (LAR) protein tyrosine phosphatase activity. Neuroscience 102 (2001) 833-841.
  • Cuppen, E., van Ham, M., Wansink, D.G., de Leeuw, A., Wieringa, B. and Hendriks, W.: The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL. Eur. J. Cell Biol. 79 (2000) 283-293.
  • van den Maagdenberg, A.M.J.M., Bächner, D., Schepens, J.T.G., Peters, W., Fransen, J.A.M., Wieringa, B. and Hendriks, W.J.A.J.: The mouse Ptprr gene encodes two protein tyrosine phosphatases, PTP-SL and PTPBR7, that display distinct patterns of expression during neural development. Eur. J. Neurosci. 11 (1999) 3832-3844.
  • Cuppen, E., Gerrits, H., Pepers, B., Wieringa, B. and Hendriks, W.: PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL. Mol. Biol. Cell 9 (1998) 671-683.
  • Schaapveld, R.Q.J., Schepens, J.T.G., Robinson, G.W., Attema, J., Oerlemans, F.T.J.J., Fransen, J.A.M., Streuli, M., Wieringa, B., Hennighausen, L. and Hendriks, W.J.A.J.: Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity. Dev. Biol. 188 (1997) 134-146.
  • KUN III.129701: The PDZ motif: a novel protein domain involved in submembranous architecture and signal transduction (W. Hendriks).
  • EU-TMR Network 97-0142: The role of protein tyrosine phosphatases IA-2 and IA-2b in neuroendocrine secretion (co-ordinator: W. Hendriks; other participants: E. Bonifacio, M. Christie, R. Lammers, N.P. Møller.
  • KWF KUN 98-1810: Protein Tyrosine Phosphatase LAR signaling and apoptosis in mammary epithelial cells (W. Hendriks).
  • NWO-ALW 809-38-004: Binding characteristics of PTP-BL PDZ motifs (W. Hendriks).
  • EU-TMR Network 99-00447: The Role of Protein Tyrosine Phosphatases in the Development and Repair of the Vertebrate Nervous System (co-ordinator: A. Stoker; other participants: R. Pulido, W. Hendriks, B. Mueller, J. den Hertog, E. Peles, A. Logan, F. Rudert, M. Mann; www.ich.ucl.ac.uk/rtnhtml/ptpnetwork.html.
  • NWO-ALW 811-37-003: Protein tyrosine phosphatase LAR signaling in neurite outgrowth and repair (W. Hendriks).
  • KUN III.120201: Dynamic aspects of the STEP-like protein tyrosine phosphatase - MAP kinase interaction in neuronal cells (W. Hendriks)