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Prof. Dr. Bart-Jan Kullberg
Research interests include involvement of cytokines and innate host defense in infection, and immunotherapy of infection, in addition to pathogenesis, immunology and therapy of invasive fungal infections. Current projects include unravelling the differential activation of Toll-like receptors (TLR) depending on structural variations of pathogen-associated molecular patterns, and the role of TLR in the Thelper1/Thelper2 bias. His group recently has described the role of TLRs in immunity against invasive fungal infections and the impact of phenotypic switching by fungi on evasion from immune recognition. Translational research has resulted in preclinical and clinical studies on immunotherapy of invasive fungal infections. |
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Recent key publications Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, van Spriel AB, Venselaar H, Elbers CC, Johnson MD, Cambi A, Huysamen C, Jacobs L, Jansen T, Verheijen K, Masthoff L, Morré SA, Vriend G, Williams DL, Perfect JR, Joosten LA, Wijmenga C, van der Meer JW, Adema GJ, Kullberg BJ, Brown GD, Netea MG. Human dectin-1 deficiency and mucocutaneous fungal infections. N Engl J Med 2009; 361: 1760-7. Van de Veerdonk FL, Marijnissen RJ, Kullberg BJ, Koenen HJ, Cheng SC, Joosten I, van den Berg WB, Williams DL, van der Meer JW, Joosten LA, Netea MG. The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe 2009; 5: 329-40. Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc Natl Acad Sci U S A 2009; 106: 10272-7. Netea MG, Brown GD, Kullberg BJ, Gow NA. An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 2008; 6: 67-78. Ferwerda EB, McCall MBB, Alonso S, Giamarellos-Bourboulis EJ, Mouktaroudi M, Izagirre N, Syafruddin D, Kibiki G, Cristea T, Hijmans A, Troye-Blomberg M, Maiga B, Dolo A, Doumbo O, Hermsen R, Stalenhoef AFH, Van Crevel R, Brunner HG, De la Rúa C, Sauerwein R, Kullberg BJ, Van der Ven AJ, Van der Meer JWM, Netea MG. TLR4 polymorphisms, infectious diseases and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci USA 2007;104:16645-50. |
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