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Medical Microbiology
Radboud University
PO Box 9101
6500 HB Nijmegen
The Netherlands
T: +31 24 3617574
F: +31 24 3614666

Frank van Kuppeveld is head of the Molecular Virology research group, which investigates the molecular, cellular and immunological aspects of picornavirus replication and pathogenesis. He was awarded an NWO-VIDI grant in 2003 and the "Beijerink premie" (an award from the Royal Dutch Academy of Sciences) in 2004 for his outstanding research in Molecular Virology.
Dr. Frank van Kuppeveld

Picornaviruses (enteroviruses, rhinoviruses, cardioviruses, parechoviruses, foot-and-mouth-disease virus, hepatitis A virus and others) alter cellular functions to facilitate virus reproducton and to evade infection-limiting antiviral host cell responses. Current projects are aimed at identification of the viral proteins responsible for these effects and elucidation of the underlying mechanisms. In addition, the putative pathogenic role of picornaviruses in chronic inflammatory diseases in humans is investigated, focusing on the role of enteroviruses in type I diabetes and the possible role of human Theiler-like cardioviruses in multiple sclerosis.
 
Recent key publications

de Jong A, de Mattia F, van Dommelen M, Lanke K, Melchers W, Willems P, van Kuppeveld F. 2008. Functional analysis of picornavirus 2B proteins: Effects on calcium homeostasis and intracellular protein trafficking. J Virol 82:3782-3790.

Kramer M, Schulte B, Toonen L, Barral P, Fisher P, Lanke K, Galama J, van Kuppeveld F, Adema G. 2008. Phagocytosis of picornavirus infected cells induces an RNA-dependent antiviral state in human dendritic cells. J Virol 82:2930-2937.

Hato S, Ricour C, Schulte B, de Bruijni M, Zoll J, Melchers W, Michiels T, van Kuppeveld F. 2007. The Mengovirus Leader Protein Blocks Interferon- α/β Gene Transcription and Inhibits Activation of Interferon Regulatory Factor 3. Cell Microbiol 9:2921-2930.

Wessels E, Duijsings D, Niu T, Neumann S, Oorschot V, de Lange F, Lanke K, Klumperman J, Henke A, Jackson C, Melchers W, van Kuppeveld F. 2006. A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1. Dev Cell 11:191-201.

van Kuppeveld F, de Jong A, Melchers W, Willems P. 2005. Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive? Trends Microbiol. 13:41-44.