Description of theme 1
Description of theme 2
Description of theme 3
   
 

Biomolecular Chemistry
PO Box 9101
NL-6500 HB Nijmegen
The Netherlands
Geert Grooteplein 28 6525 GA, Nijmegen T: +31 24 361 6847
F: +31 24 354 0525

Ger Pruijn is professor in Biomolecular Chemistry since 2006. He acts as head of the Department of Biomolecular Chemistry of the Institute for Molecules and Materials (IMM), Faculty of Science, Mathematics and Computing Science.
 
Dr. Ger Pruijn

Research interests include biochemistry and molecular biology, with a specific focus on the molecular aspects of autoimmunity. Major current projects include the structure and function of autoantigenic macromolecular complexes and the role of posttranslational modifications in autoimmunity. Most of the macromolecular complexes studied represent ribonucleoprotein particles / protein complexes involved in RNA metabolism in human cells. Studies on the intriguing relationship between (unusual) protein modifications and the anti-self response in autoimmune patients are focused on rheumatoid arthritis, myositis and multiple sclerosis.
 
Recent key publications

Schilders G, Pruijn GJ. Biochemical studies of the mammalian exosome with intact cells. Methods Enzymol. 2008;448:211-26.

Welting TJ, Mattijssen S, Peters FM, van Doorn NL, Dekkers L, van Venrooij WJ, Heus HA, Bonafé L, Pruijn GJ. Cartilage-hair hypoplasia-associated mutations in the RNase MRP P3 domain affect RNA folding and ribonucleoprotein assembly. Biochim Biophys Acta. 2008 Mar;1783(3):455-66. Epub 2007 Dec 8.

Lokate AM, Beusink JB, Besselink GA, Pruijn GJ, Schasfoort RB. Biomolecular interaction monitoring of autoantibodies by scanning surface plasmon resonance microarray imaging. J Am Chem Soc. 2007 Nov 14;129(45):14013-8. Epub 2007 Oct 17.

Schilders G, Egberts WV, Raijmakers R, Pruijn GJ. C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome. Arthritis Rheum. 2007 Jul;56(7):2449-54.

Van Dijk EL, Schilders G, Pruijn GJ. Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. RNA. 2007 Jul;13(7):1027-35. Epub 2007 Jun 1.