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Rheumatology
PO Box 9101
6500 HB Nijmegen
T:+31 24 361 9805
F:+31 24 354 0403

Wim van den Berg is a biochemist, is head of the rheumatology research lab and professor of of experimental rheumatology since 1992. He is a former secretary general of the osteoarthritis research society international (OARSI) and is president of the international association of inflammation societies (IAIS). He has received the OARSI basic research award and the Dutch Federa award for his life time achievements in research on joint destruction in arthritis and osteoarthritis.
Prof Wim B van den Berg

Research interests are focused on the role of cytokines and growth factors in chronicity of joint inflammation and mechanisms of destruction of cartilage and bone. Major expertise is in the development of murine models for arthritis and osteoarthritis and in the translation of experimental findings to advanced therapeutic modalities, including gene therapy.
 
Recent key publications

Koenders MI, Lubberts E, Oppers-Walgreen B, van den Bersselaar L, Helsen MMA, Kolls JK, Joosten LAB, van den Berg WB: Induction of cartilage damage by overexpression of T cell IL-17A in experimental arthritis in mice deficient in IL-1. Arthritis Rheum, 52: 975-983, 2005
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Koenders MI, Lubberts E, Oppers-Walgreen B, van den Bersselaar L, Helsen MMA, Di Padova FE, Boots AMH, Gram H, Joosten LAB, van den Berg WB: Blocking of IL-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and IL-1. Am J Pathol, 167: 141-149, 2005.

Koenders MI, Kolls JK, Joosten LAB, Oppers-Walgreen B, van den Bersselaar L, Joosten LAB, Schurr JR, Schwarzenberger P, van den Berg WB, Lubberts EL: IL-17 receptor deficiency results in impaired synovial expression of IL-1 and MMP-3, -9, -13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis. Arthritis Rheum, 52: 3239-3247, 2005.

Lubberts E, Schwarzenberger P, Huang W, Schurr JR, Peschon JJ, van den Berg WB, Kolls JK: Requirement of IL-17 receptor signaling in resident synoviocytes for development of full blown destructive arthritis. J Immunol, 175: 3360-3368, 2005.

Lubberts E, Schwarzenberger P, Huang W, Schurr JR, Peschon JJ, van den Berg WB, Kolls JK: Requirement of IL-17 receptor signaling in resident synoviocytes for development of full blown destructive arthritis. J Immunol, 175: 3360-3368, 2005.

Nabbe KCAM, Boross P, Holthuysen AEM, Sloetjes AW, Kolls JK, Verbeek JS, van Lent PLEM, van den Berg WB: Joint inflammation and chondrocyte death become independent of FcgrIII by local overexpression of IFN-g during immune complex arthritis. Arthritis Rheum, 52 : 967-974, 2005.

Roelofs MF, Joosten LAB, Abdollahi-Roodsaz S, van Lieshout AWT, Sprong T, van den Hoogen FH, van den Berg WB, Radstake TRDJ: The expression of Toll-like receptor 3 and 7 in RA synovium is increased and costimulation of TLR3, 4, 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum, 52: 2313-2322, 2005.

Smeets RL, Joosten LAB, Arntz OJ, Bennink MB, Takahashi N, Carlsen H, Martin MU, van den Berg WB, van de Loo: Soluble IL-1ra protein ameliorates collagen-induced arthritis by a different mode of action from that of IL-1ra. Arthritis Rheum, 52: 2202-2211, 2005.