Adema

Adema, Gosse
Name:
Prof. Gosse Adema

Function:
Full Professor

Theme:
Immune Regulation


Profile

Research interests focus on the molecular analysis of professional antigen presenting dendritic cells and T-regulatory cells, and their function in the immune system in health and disease. Major current projects include i) functional analysis of DC-SCRIPT and Pattern Recognition Receptors in dendritic cell biology and ii) pre-clinical mouse studies on the role of dendritic cells and T-regulatory cells in immunotherapy of cancer and iii) development of immuno-combination therapies aiming to induce anti-tumor immune responses and to reverse the immune suppressive tumor microenvironment. The knowledge gathered in the fundamental immunological studies is translated into clinical vaccination studies of cancer patients with autologous, antigen-loaded dendritic cell vaccines.

Gosse Adema holds the chair in Molecular Immunology at the department of Tumor Immunology and is theme leader of the NCMLS research Theme 1- Infection, Immunity and Tissue repair.

Recent key publications

  • Zeelenberg IS, van Maren WW, Boissonnas A, Van Hout-Kuijer MA, Den Brok MH, Wagenaars JA, van der Schaaf A, Jansen EJ, Amigorena S, Théry C, Figdor CG, Adema GJ. Antigen Localization Controls T Cell-Mediated Tumor Immunity. J Immunol. 187:1281-8, 2011. 

  • Jacobs JF, Punt CJ, Lesterhuis WJ, Sutmuller RP, Brouwer HM, Scharenborg NM, Klasen IS, Hilbrands LB, Figdor CG, de Vries IJ, Adema GJ. Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients. Clin Cancer Res. 16:5067-78, 2010.

  • Schuurhuis DH, Verdijk P, Schreibelt G, Aarntzen EH, Scharenborg N, de Boer A, van de Rakt MW, Kerkhoff M, Gerritsen MJ, Eijckeler F, Bonenkamp JJ, Blokx W, van Krieken JH, Boerman OC, Oyen WJ, Punt CJ, Figdor CG, Adema GJ, de Vries IJ. In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients. Cancer Res. 69:2927-34, 2009. 

  • Nierkens S, den Brok MH, Sutmuller RP, Grauer OM, Bennink E, Morgan ME, Figdor CG, Ruers TJ, Adema GJ. In vivo colocalization of antigen and cytidyl guanosyl within dendritic cells is associated with the efficacy of cancer immunotherapy. Cancer Res. 68:5390-6, 2008. 

  • Meyer-Wentrup F, Benitez-Ribas D, Tacken PJ, Punt CJ, Figdor CG, de Vries IJ, Adema GJ. Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production. Blood. 111:4245-53, 2008. 

Keywords:  Cancer /


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