Cohen

Cohen , Adrian2
Name:
Dr. Adrian Cohen

Function:
Scientific Manager

Theme:


Profile

Adrian Cohen obtained a first class honours degree (BSc) in Pharmacology at the University of Sunderland in 1998. In 2001, I obtained my doctoral degree from the University of Glasgow and studying the mechanism of action of two purine-analogues against a Toxoplasma gondii parasite. In 2001, I joined Galapagos genomics as a junior group leader (responsible for the incorporation of proteomics technologies into the Company's platform for the validation of gene targets for Psoriasis, Osteoporosis and Alzheimer's disease) and in 2004 joined Prof. Stunnenberg's lab at the NCMLS as a postdoctoral researcher (analysis of histone modifications in Malaria parasite). In 2005 I became the project manager for a number of EU FP6 projects and in April 2007 became a full-time scientific manager for NCMLS. My formal position is with the RUNMC as a research policy advisor. I am responsible for scientific manangement and strategy at NCMLS. Tasks include internationalisation, grant writing, Graduate School (Masters & PhD) advisor, talent recruitment, international symposium organisation, lectures and seminars, manager NCMLS secretariaat.

Recent key publications

  • Nagy Z, Riss A, Fujiyama S, Krebs A, Orpinell M, Jansen P, Cohen A, Stunnenberg HG, Kato S, Tora L. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Cell Mol Life Sci. 67:611-28, 2010.

  • Nekrasov M, Klymenko T, Fraterman S, Papp B, Oktaba K, Köcher T, Cohen A, Stunnenberg HG, Wilm M, Müller J. Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J. 26:4078-88, 2009.

  • Trelle MB, Salcedo-Amaya AM, Cohen AM, Stunnenberg HG, Jensen ON. Global histone analysis by mass spectrometry reveals a high content of acetylated lysine residues in the malaria parasite Plasmodium falciparum. J Proteome Res. 8:3439-50, 2009.

  • Salcedo-Amaya AM, van Driel MA, Alako BT, Trelle MB, van den Elzen AM, Cohen AM, Janssen-Megens EM, van de Vegte-Bolmer M, Selzer RR, Iniguez AL, Green RD, Sauerwein RW, Jensen ON, Stunnenberg HG. Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum. Proc Natl Acad Sci U S A. 106:9655-60, 2009.

  • Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science. 323:946-51, 2009.

  • Le Guezennec X, Vermeulen M, Brinkman AB, Hoeijmakers WA, Cohen A, Lasonder E, Stunnenberg HG. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol Cell Biol. 26:843-51, 2006.




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