Profile
Research interest is the visualization of cell-matrix interactions and dynamic cell patterning during immune cell interactions and tumor invasion. We, therefore, use 3D extracellular matrix (ECM) based cell culture models and advanced imaging procedures. Recently, the group moved into in vivo-imaging of tumor and immune cell migration by multiphoton microscopy. This complements in vitro culture technology. These approaches have provided insight into the serial dynamics of T cell scanning across antigen-presenting cells and the diversity of tumor invasion mechanisms, as well as novel escape responses in tumor cell migration. New technology allows imaging deep into tumours (video-interview)
Peter Friedl holds the chair for Microscopical Imaging of the Cell at the NCMLS since October 2007, which includes the Core Facility for Microscopy at the Radboud University Nijmegen Medical Center. In addition, he fulfills the role of the head of the Cell Dynamics Laboratory and, since 11/2011 has a joint-appointment joint-faculty position as head of the imaging section at the David H. Koch Center, Department of Genitoureteal Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Recent key publications
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Friedl P & Alexander S. Cancer Invasion and the Microenvironment: Plasticity and Reciprocity. Cell, Volume 147, Issue 5, 992-1009, 2011
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Friedl P, Wolf K. Plasticity of cell migration: a multiscale tuning model. J Cell Biol. 188:11-9, 2010.
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Friedl, P. and D. Gilmour. Collective cell migration in development, regeneration and cancer. Nat. Rev. Mol. Cell Biol. 10:445-457, 2009.
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Andresen V, Alexander S, Heupel WM, Hirschberg M, Hoffman RM, Friedl P. Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr Opin Biotechnol. 20:54-62, 2009.
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Friedl P, Weigelin B. Interstitial leukocyte migration and immune function. Nat Immunol. 9:960-9, 2008.
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Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P. Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol. 9:893-904, 2007.
Keywords: Cancer /
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