Profile
Research focuses on wound healing and scarring after cleft palate repair. Scar formation in the mucosa and muscles of the palate after surgery causes growth disturbances of the upper jaw and impairs speech. Research focuses on strategies to reduce scarring in mucosa/skin and muscle tissue. This includes in vitro studies on fibroblasts and muscle cells as well as animal models for wound healing in mucosa/skin and muscle. Scaffolds with specific growth factors and structural cues are developed to improve the healing of these tissues. The final aim is to improve the outcome of cleft palate surgery with respect to growth and function.
Dr. Von den Hoff is a cell biologist and assistant professor at the department of Orthodontics and Craniofacial Biology in Dentistry. He is also board member of the European Tissue Repair Society.
Recent key publications
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Ten Broek RW, Grefte S, Von den Hoff JW. Regulatory factors and cell populations involved in skeletal muscle regeneration. JCellPhysiol. 224:7-16, 2010.
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Grefte S, Kuijpers-Jagtman AM, Torensma R, Von den Hoff JW. Model for muscle regeneration around fibrotic lesions in recurrent strain injuries. Med Sci Sports Exerc. 42:813-9, 2010.
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Liu J, Bian Z, Kuijpers-Jagtman AM, Von den Hoff JW. Skin and mucosa equivalents: construction and performance. Orthod Craniofac Res. 13:11-20, 2010.
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Jansen RG, van Kuppevelt TH, Daamen WF, Kuijpers-Jagtman AM, Von den Hoff JW. FGF-2-loaded collagen scaffolds attract cells and blood vessels in rat oral mucosa. JOralPathol Med. 38:630-8, 2009.
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Meng L, Bian Z, Torensma R, Von den Hoff JW. Biological mechanisms in palatogenesis and cleft palate. J Dent Res. 88:22-33, 2009.
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Verstappen J, Katsaros K, Kuijpers-Jagtman AM, Torensma R, Von den Hoff JW.
Wound Rep Reg 19:260-267, 2011.
Keywords: Congenital disorders /
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