Profile
Research interests focus on the understanding of the development of cancer of the immune system and colorectal cancer, especially the relationship between tumor cells and the host response. Methodologies include all aspects of tissue evaluation (histology, immunohistochemistry, in situ hybridization, micro tissue array ) and molecular methods (clonality assessment, MSI-testing, high throughput genomics and proteomics). All studies are oriented towards patient material and its application in the practice of pathology.
Han van Krieken is a pathologist with special expertise in the fields of hematopathology and the pathology of the gastrointestinal tract. He is professor of Tumor Pathology since 1999 and is, since 2004, acting head of the Pathology Department. He is the treasurer of the European Association for Haematopathology and is the secretary/treasurer of the European Society for Pathology.
Recent key publications
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Nagtegaal ID, van de Velde CJ, Marijnen CA, van Krieken JH, Quirke P; Dutch ColorectalCancerGroup; Pathology Review Committee. Low rectal cancer: a call for a change of approach in abdominoperineal resection. J Clin Oncol. 23:9257-64, 2005.
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de Vries IJ, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, Oyen WJ, Bonenkamp JJ, Boezeman JB, Adema GJ, Bulte JW, Scheenen TW, Punt CJ, Heerschap A, Figdor CG. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol. 23:1407-13, 2005.
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Schraders M, Pfundt R, Straatman HM, Janssen IM, van Kessel AG, Schoenmakers EF, van Krieken JH, Groenen PJ. Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization. Blood. 105:1686-93, 2005.
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Koster A, van Krieken JH, Mackenzie MA, Schraders M, Borm GF, van der Laak JA, Leenders W, Hebeda K, Raemaekers JM. Increased vascularization predicts favorable outcome in follicular lymphoma. Clin Cancer Res. 11:154-61, 2005.
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