Profile
Mihai Netea's main research
interests are the mechanisms of pattern recognition of fungal
pathogens, especially Candida albicans, and the immunopathogenetic
mechanisms of sepsis.
Immune responses can be divided into innate host responses thought
to act naively to each encounter with a pathogen, and adaptive (or
specific) immune responses that build memory to the encounter with
a pathogenic microorganism. A deeper understanding of the
mechanisms of immunological memory of the mammalian innate host
responses will unravel a completely new aspect of the immune
response, and could represent the basis of novel strategies of
immunotherapy and vaccination.
Recent key publications
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van de Veerdonk FL, Marijnissen RJ, Kullberg BJ, Koenen HJ, Cheng SC, Joosten I, van den Berg WB, Williams DL, van der Meer JW, Joosten LA, Netea MG. The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe. 5:329-40, 2009.
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Netea MG, Nold-Petry CA, Nold MF, Joosten LA, Opitz B, van der Meer JH, van de Veerdonk FL, Ferwerda G, Heinhuis B, Devesa I, Funk CJ, Mason RJ, Kullberg BJ, Rubartelli A, van der Meer JW, Dinarello CA. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood. 113:2324-35, 2009.
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Netea MG, Brown GD, Kullberg BJ, Gow NA. An integrated model of the recognition of Candida albicans by the innate immune. Nat Rev Microbiol. 6:67-78, 2008.
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Ferwerda B, McCall MB, Alonso S, Giamarellos-Bourboulis EJ, Mouktaroudi M, Izagirre N, Syafruddin D, Kibiki G, Cristea T, Hijmans A, Hamann L, Israel S, ElGhazali G, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Hermsen CC, Stalenhoef AF, van Crevel R, Brunner HG, Oh DY, Schumann RR, de la Rúa C, Sauerwein R, Kullberg BJ, van der Ven AJ, van der Meer JW, Netea MG. TLR4 polymorphisms, infectious diseases, and evolutionary pressure during. Proc Natl Acad Sci U S A. 104:16645-50, 2007.
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